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Tocris Bioscience™ Echinomycin
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Artikelnummer. 18746736
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Mængde:
1 mg
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18746736 1 mg
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Artikelnummer. 18746736 Leverandør Tocris Bioscience™ Leverandørnr. 5520/1

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Beskrivelse

Highly potent and selective HIF-1α inhibitor

Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale Echinomycin
CAS 512-64-1
Synonym N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether
Mængde 1 mg
Opløselighed Soluble to 5mM in DMSO
Molekylær formel C51H64N12O12S2
Formel vægt 1101.26
Fysisk form Solid
Produkttype Bioactive Small Molecule
Renhed >98%

Research Use Only. Not For Human or Veterinary Use

Produkttitel
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