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Tocris Bioscience™ ABT 089 Dihydrochloride
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Artikelnummer. 18770149
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10 mg
50 mg
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18770149 50 mg
18766258 10 mg
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Artikelnummer. 18770149 Leverandør Tocris Bioscience™ Leverandørnr. 5079/50

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Beskrivelse

High affinity and selective α4β2 nAChR partial agonist

ABT 089 dihydrochloride is a high affinity and selective α4β2 partial agonist (Ki = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant.
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Tekniske data

Kemisk navn eller materiale ABT 089 dihydrochloride
CAS 161416-61-1
Synonym 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride
Mængde 50 mg
Opløselighed Soluble to 100mM in water and to 20mM in DMSO
Molekylær formel C11H16N2O·2HCl
Formel vægt 265.18
Fysisk form Solid
Produkttype Bioactive Small Molecule
Renhed >98%

Research Use Only. Not For Human or Veterinary Use

Produkttitel
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