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Quizartinib, MedChemExpress

Artikelnummer. 16486056
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Pakningsstørrelse:
50mg
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16486056 100 mg -
16475468 10 mg -
16461056 200 mg -
16451647 50 mg 50mg
16428187 5 mg -
16401656 500 mg -
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Artikelnummer. 16486056 Leverandør Medchem Express Leverandørnr. HY13001

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Beskrivelse

MedChemExpress Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis.

Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis.

Tekniske data

Kemisk navn eller materiale Quizartinib
CAS 950769-58-1
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C29H32N6O4S
Mængde 100 mg
Synonym AC220
Opløselighedsinformation DMSO : ≥ 33 mg/mL (58.86 mM)
SMIL O=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C=C2)C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3
Molekylvægt (g/mol) 560.67
Formel vægt 560.67
Procent renhed 98.87%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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