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STEMCELL Technologies QNZ

Artikelnummer. 17120212
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1 mg
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17120212 1 mg
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Artikelnummer. 17120212 Leverandør STEMCELL Technologies Leverandørnr. 73352

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Beskrivelse

NF-kB pathway inhibitor; Inhibits NF-kB

  • QNZ is a quinazoline derivative that inhibits nuclear factor (NF)-κB activation (IC50 = 11 nM in human Jurkat T lymphocyte cells)
  • NF-κB enhances the transcription of pro-inflammatory cytokines, and QNZ inhibits lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF)-α production in mouse splenocytes (IC50 = 7 nM;Tobe et al.), as well as CXCL1-mediated pro-inflammatory increase in potassium currents in adult rat neurons (Yang et al)
  • It does not inhibit kinases in a standard screen (Wu et al.)
  • Neuroprotective in a glutamate toxicity assay using YAC128 medium spiny neuron cultures (Wu et al.)
  • Blocks amyloid precursor protein release in human SH-SY5Y neuroblastoma cells caused by muscarinic receptor activation (Choi et al.)

Tekniske data

CAS 545380-34-5
Synonym CAY10470
Mængde 1 mg
Molekylær formel C22H20N4O
Renhed ≥98%
Produkttitel
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