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Pyr10, MedChemExpress Product Code.: 16450228

Pyr10, MedChemExpress

Product Code. p-200096619
5 mg, 5mg
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Product Code. 16450228

Brand: Medchem Express HY19408

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MedChemExpress Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 ÎĽM (IC50 of 13.08 ÎĽM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels.

Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 ÎĽM (IC50 of 13.08 ÎĽM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels.

Specifications

Chemical Name or Material Pyr10
CAS 1315323-00-2
Color Off-White
Purity Grade Notes Research
Molecular Formula C18H13F6N3O2S
Quantity 5 mg
Solubility Information DMSO : 100 mg/mL (222.53 mM; Need ultrasonic)
SMILES O=S(C1=CC=C(C)C=C1)(NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2)=O
Molecular Weight (g/mol) 449.37
Formula Weight 449.37
Percent Purity 97.52%
Grade Research
Physical Form Solid
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Research purposes only

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