Invitrogen™ Human PUMA Synthetic Peptide

Description

PUMA Synthetic Peptide, PEP-0128, from Invitrogen.

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. This peptide corresponds to 15 amino amino terminus of human PUMA.PEP-0128 can be used as a blocking peptide with polyclonal antibody PA5-20008.