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Tocris Bioscience™ Pridopidine
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Artikelnummer. 18799946
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10 mg
50 mg
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Artikelnummer. Mængde
18799946 10 mg
18706056 50 mg
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Artikelnummer. 18799946 Leverandør Tocris Bioscience™ Leverandørnr. 7630/10

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Beskrivelse

Highly selective σ1 agonist

Pridopidine is a selective high affinity σ-1 receptor (S1R) agonist (Ki = 7.1 nM in both HEK293 cells and rat striatal membranes). Pridopidine displays ∼30-fold and ∼100-fold selectivity over the dopamine D3 receptor and the D2 receptor, respectively. Pridopidine is a low affinity dopamine D2 receptor antagonist (Ki (low) = 17.5 μM; Ki (high) = 7.5 μM). Pridopidine upregulates gene expression induced by BDNF in rat striatum in vivo in an S1R-dependent manner. Pridopidine improves motor function and shows neuroprotective effects in Huntington's disease animal models. Pridopidine restores neuromuscular junction activity in amyotrophic lateral sclerosis models in vitro and in vivo. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine
CAS 346688-38-8
Mængde 10 mg
Mål Sigma1 Receptor Agonists
Molekylær formel C15H23NO2S
Renhed 98%
Produkttitel
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