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Invitrogen™ PRAS40 Monoclonal Antibody (73P21)

Beskrivelse
PRAS40 Monoclonal Antibody for Western Blot, IHC (P), ICC/IF, IP
The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can induce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
Tekniske data
Tekniske data
| Antigen | PRAS40 |
| Applikationer | Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry |
| Klassifikation | Monoclonal |
| Klon | 73P21 |
| Koncentration | 0.5 mg/mL |
| Konjugeret | Unconjugated |
| Formulering | PBS with 1% BSA and 0.1% sodium azide |
| Gene | AKT1S1 |
| Genadgangsnr. | Q96B36 |
| Gene Alias | 1110012J22Rik; 40 kDa proline-rich AKT substrate; AI227026; AKT1 substrate 1; AKT1 substrate 1 (proline rich); AKT1 substrate 1 (proline-rich); akt1s1; Lobe; Lobel; OTTHUMP00000196756; OTTHUMP00000196760; PKB/Akt substrate 40; Pras; PRAS40; Proline-rich AKT substrate; proline-rich AKT1 substrate 1 |
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Produkttitel
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