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STEMCELL Technologies PP1

Artikelnummer. 17160172
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Mængde:
1 mg
10 mg
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Artikelnummer. Mængde
17160172 1 mg
17170172 10 mg
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Artikelnummer. 17160172 Leverandør STEMCELL Technologies Leverandørnr. 73112

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Beskrivelse

Tyrosine kinase inhibitor; Inhibits LCK, FYN, HCK, and SRC

  • PP1 is a reversible inhibitor of the SRC family of tyrosine kinases
  • It inhibits LCK, FYN, HCK and SRC with IC50 values of 5, 6, 20 and 170 nM, respectively (Hanke et al.) It is relatively selective for SRC family kinases versus other kinases, inhibiting epidermal growth factor receptor (EGFR), janus-activated kinase 2 (JAK2) and zeta-chain-associated protein kinase 70 (ZAP70) with IC50 values of 0.25, > 50, and > 100 μM, respectively, and KIT, platelet-derived growth factor receptor (PDGFR), and RET tyrosine kinase in the 75 - 100 nM range (Carlomagno et al.; Tatton et al.; Waltenberger et al.; Hanke et al.) PP1 also blocks TGF-β-mediated cellular responses by directly inhibiting type I TGF-β receptors (IC50 = 50 nM; Ungefroren et al.; Maeda et al.)

Tekniske data

CAS 172889-26-8
Synonym AGL 1872; EI 275
Mængde 1 mg
Molekylær formel C16H19N5
Renhed ≥98%
Produkttitel
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