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Tocris Bioscience™ PP 242
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Artikelnummer. 18766436
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Mængde:
5 mg
25 mg
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Artikelnummer. Mængde
18766436 25 mg
18707446 5 mg
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Artikelnummer. 18766436 Leverandør Tocris Bioscience™ Leverandørnr. 4257/25

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Beskrivelse

Dual mTORC1/mTORC2 inhibitor

PP 242 is an ATP-competitive mTORC1/mTORC2 inhibitor (IC50 = 8 nM). Displays selectivity for mTOR over other PI 3K family kinases (IC50 values are 0.102, 0.408, 1.27, 1.96 and 2.2 μM for p110γ, DNA-PK, p110δ, p110α and p110β respectively) and 215 further kinases. Displays modest inhibition of PKCα, JAK2, PKCβI, PKCβII and RET (IC50 values are 0.049, 0.110, 0.185, 0.198 and 0.224 μM respectively). Inhibits both S6K and 4EBP1 phosphorylation; activity causes a decrease in cap-dependent protein translation. Also triggers downregulation of cFLIPS and augments TRAIL-induced apoptosis of cancer cells. PP 242 also inhibits oncogenic K-Ras and PI 3-K induced lipogenesis in breast cancer cells.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol
CAS 1092351-67-1
Analyseprocentområde >98%
Mængde 25 mg
Molekylær formel C16H16N6O
Formel vægt Observed MW: 308.34
Produkttitel
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