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Invitrogen™ PMP70 Polyclonal Antibody

Artikelnummer. 11523651
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Mængde:
100 μg
Pakningsstørrelse:
100µg
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11523651 100 μg 100µg
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Artikelnummer. 11523651 Leverandør Invitrogen™ Leverandørnr. PA1650
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Brug rabatkode 27967
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3543.00 DKK valid until 2026-12-18
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Beskrivelse

Rabbit Polyclonal Antibody

PA1-650 detects peroxisomal membrane protein 70 (PMP70) from mouse tissues. PA1-650 has been successfully used in Western blot, flow cytometry, and immunofluorescence procedures. By Western blot, this antibody detects an ~70 kDa protein representing PMP70 from peroxisome-enriched fractions from L cells. PA1-650 immunizing peptide corresponds to amino acid residues 644-659 from rat PMP70. This sequence is completely conserved in mouse PMP70 and differs from human PMP70 by a single amino acid substitution. PA1-650 immunizing peptide (Cat. # PEP-038) is available for use in neutralization and control experiments.

Peroxisomes are single membrane organelles which are involved with many important biochemical pathways and are found in almost all eukaryotic cells. Various toxins including, phenols, alcohols, and aldehydes are targeted for modification by peroxisomes. Long chain fatty acid metabolism via beta-oxidation is also mediated by this organelle. Loss of peroxisomal functions may result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsum' disease. Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome. This protein is induced by treatment with hypolipidemic agents in parallel with peroxisome proliferation and stimulation of the peroxisomal beta-oxidation enzymes.
TRUSTED_SUSTAINABILITY

Tekniske data

Antigen PMP70
Applikationer Flow Cytometry, Western Blot, Immunocytochemistry
Klassifikation Polyclonal
Koncentration 1 mg/mL
Konjugeret Unconjugated
Formulering PBS with 1mg/mL BSA and 0.05% sodium azide
Gene ABCD3
Genadgangsnr. P16970, P28288, P55096
Gene Alias 68 kDa peroxisomal membrane protein; 70 kDa peroxisomal membrane protein; 70-kDa peroxisomal membrane protein; ABC43; ABCD3; AI313901; ATP binding cassette subfamily D member 3; ATP-binding cassette sub-family D member 3; ATP-binding cassette, subfamily D (ALD), member 3; ATP-binding cassette, sub-family D (ALD), member 3; AU018866; AW146054; CBAS5; dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1)); Peroxisomal membrane protein 1; peroxisomal membrane protein 1 (70kD, Zellweger syndrome); peroxisomal membrane protein, 70 kDa; Peroxisomal membrane protein-1 (70kD); PMP68; Pmp70; Pxmp1; ZWS2
Gensymboler ABCD3
Værtsarter Rabbit
Immunogen Synthetic Peptide: C N(644) Y E F K K I T E D T V E F G S(659).
Oprensningsmetode Antigen affinity chromatography
Mængde 100 μg
Regulatorisk status RUO
Primær eller sekundær Primary
Gen-id (Entrez) 19299, 25270, 5825
Målarter Human, Mouse, Rat
Indhold og opbevaring -20°C, Avoid Freeze/Thaw Cycles
Produkttype Antibody
Form Liquid
Isotype IgG
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