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Tocris Bioscience™ PIK 90
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Artikelnummer. 30000036
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30000036 50 mg
30000011 10 mg
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Artikelnummer. 30000036 Leverandør Tocris Bioscience™ Leverandørnr. 7902/50

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Beskrivelse

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

PIK 90 is a potent inhibitor of PI 3-K α/γ/δ kinases (IC50 = 11, 18, 47, 58 and 64 nM against p110α, p110γ, PI 3-KC2α, p110δ and PI 3-KC2α, respectively) as well as PIKKs (IC50 = 13 nM against DNA-PK). It inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells. It suppresses insulin-stimulated phosphorylation of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes in vitro and prevents insulin-induced blood glucose reduction in mice in vivo. PIK 90 can be used in combination with other small molecules and proteins for mesendoderm induction in protocols to differentiate iPSCs into organ-specific mesenchyme.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide
CAS 677338-12-4
Mængde 50 mg
Mål PI 3-Kinase Inhibitors
Molekylær formel C18H17N5O3
Renhed 0.98
Produkttitel
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