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Tocris Bioscience™ Phototrexate
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Artikelnummer. 18044782
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Mængde:
5 mg
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Artikelnummer. Mængde
18044782 5 mg
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Artikelnummer. 18044782 Leverandør Tocris Bioscience™ Leverandørnr. 7362/5

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Beskrivelse

Photoswitchable inhibitor of human dihydrofolate reductase

Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate (Cat. No. 1230). Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark. cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared with trans-Phototrexate (IC50 = 34 μM).
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale N-[4-[(1 E)-2-(2,4-Diamino-6-quinazolinyl)diazenyl]benzoyl]-L-glutamic acid
CAS 2268033-83-4
Mængde 5 mg
Mål Dihydrofolate Reductase Inhibitors
Molekylær formel C20H19N7O5
Renhed 95%
Produkttitel
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