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  6. Invitrogen™ Phospho-p130 (Ser952) Recombinant Rabbit Monoclonal Antibody (K01_1X68)

Invitrogen™ Phospho-p130 (Ser952) Recombinant Rabbit Monoclonal Antibody (K01_1X68)
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Artikelnummer. 30825640
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Artikelnummer. 30825640 Leverandør Invitrogen™ Leverandørnr. MA563604

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Beskrivelse

Rabbit Recombinant Monoclonal Antibody

Phospho-p130 (Ser952) Recombinant Monoclonal Antibody for ICC/IF, IHC (P), Western Blot

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
TRUSTED_SUSTAINABILITY

Tekniske data

Antigen Phospho-p130 (Ser952)
Applikationer Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Klassifikation Recombinant Monoclonal
Klon K01_1X68
Koncentration 1 mg/mL
Konjugeret Unconjugated
Formulering 50mM tris glycine with 150mM NaCl, 0.05% BSA, 40% glycerol and 0.01% sodium azide; pH 7.4
Gene RBL2
Genadgangsnr. Q08999
Gene Alias 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RB transcriptional corepressor like 2; Rb2; rb2 p130; Rbl2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gensymboler RBL2
Værtsarter Rabbit
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser952 of human Rb2 p130.
Oprensningsmetode Protein A/G
Mængde 100 μL
Regulatorisk status RUO
Primær eller sekundær Primary
Gen-id (Entrez) 5934
Målarter Human
Indhold og opbevaring Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Produkttype Antibody
Form Liquid
Isotype IgG
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