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Phospho-LCK (Tyr505) Monoclonal Antibody (SRRCHA), eFluor™ 660, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

968.00 DKK - 2705.00 DKK

Specifications

Antigen Phospho-LCK (Tyr505)
Clone SRRCHA
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
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Product Code Brand Quantity Price Quantity & Availability  
15500077
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Affymetrix eBioscience
50-9076-42
100 Tests
2705.00 DKK
100 tests
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Estimated Shipment: 10-05-2024
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15590067
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Affymetrix eBioscience
50-9076-41
25 Tests This item is currently unavailable or has been discontinued.
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Description

Description

Description: This SRRCHA monoclonal antibody recognizes human and mouse LCK when phosphorylated on tyrosine 505 (Y505). Y505 is a negative-regulatory site that is phosphorylated by the kinase CSK. LCK is expressed in T cells where it associates with the cytoplasmic tails of the CD4 and CD8 co-receptors on T helper cells and cytotoxic T cells, respectively. When the TCR is engaged, LCK acts to phosphorylate the intracellular chains of CD3 and zeta chains of the TCR complex, allowing the cytoplasmic tyrosine kinase, ZAP-70, to bind to them. LCK then phosphorylates and activates ZAP-70, which then phosphorylates the adaptor protein, LAT, that serves as a docking site for a number of other proteins, including SLP-76, Grb2, and phospholipase C gamma1. Mice lacking expression of LCK show defects in T cell development and function. Applications Reported: This SRRCHA antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This SRRCHA antibody has been pre-titrated and tested by intracellular staining followed by flow cytometric analysis of stimulated normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Phospho-LCK (Tyr505) Monoclonal antibody specifically detects Phospho-LCK (Tyr505) in Human, Mouse samples. It is validated for Flow Cytometry.
Specifications

Specifications

Phospho-LCK (Tyr505)
5 μL/Test
Monoclonal
Liquid
RUO
P06239, P06240
LCK
Primary
4° C, store in dark, DO NOT FREEZE!
LCK
SRRCHA
Flow Cytometry
eFluor 660
Mouse
Human, Mouse
16818, 3932
IgG1 κ
Affinity chromatography
Antibody
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