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Beskrivelse
Profilin-1 (PFN1) plays an important role in the control of actin dynamics, and could represent an important therapeutic target in several diseases. PFN1 is identified as a huntingtin aggregation inhibitor, and may serves as a tumor-suppressor. PFN1 is crucial for the conversion of monomeric (G)-actin to filamentous (F)-actin. Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder resulting from motor neuron death. Cells expressing PFN1 mutants contain ubiquitinated, insoluble aggregates that in many cases contain the ALS-associated protein TDP-43. Recently, PFN1 is a potential biomarker for bladder cancer aggressiveness and may be of great clinical importance.
Tekniske data
Tekniske data
| Antigen | PFN1 |
| Applikationer | Immunofluorescence |
| Klassifikation | Monoclonal |
| Klon | 3A12E8 |
| Koncentration | 991 μg/mL |
| Konjugeret | CoraLite 594 |
| Værtsarter | Mouse |
| Mængde | 100 μL |
| Primær eller sekundær | Primary |
| Gen-id (Entrez) | 5216 |
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