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Tocris Bioscience™ PDD 00017273
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Artikelnummer. 18767236
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Mængde:
1 mg
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18767236 1 mg
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Artikelnummer. 18767236 Leverandør Tocris Bioscience™ Leverandørnr. 5952/1

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Beskrivelse

Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor

PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells and inhibits cancer cell survival. Cell permeable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
CAS 1945950-21-9
Mængde 1 mg
Mål PARG Inhibitors
Molekylær formel C23H26N6O4S2
Renhed 98%
Produkttitel
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