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Tocris Bioscience™ PDD 00017273
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Artikelnummer. 18749356
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Mængde:
10 mg
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18749356 10 mg
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Artikelnummer. 18749356 Leverandør Tocris Bioscience™ Leverandørnr. 5952/10

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Beskrivelse

Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeable

PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells and inhibits cancer cell survival. Cell permeable.
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Tekniske data

Kemisk navn eller materiale 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
CAS 1945950-21-9
Mængde 10 mg
Opløselighed Soluble to 100mM in water and to 100mM in DMSO
Mål PARG Inhibitors
Molekylær formel C23H26N6O4S2
Formel vægt 514.62
Fysisk form Solid
Farve White
Produkttype Bioactive Small Molecule
Renhed >98%
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For Research Use Only.

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