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STEMCELL Technologies PD98059
Beskrivelse
- PD98059 is a selective, cell permeable inhibitor of the MEK/ERK pathway that acts by preventing the activation of MEK1 (IC50 = 2 - 7 μM) and MEK2 (IC50 = 50 μM) by upstream kinases
- It does not inhibit activated MEK, or the p38 MAPK pathway
- (Alessi et al.), Davies et al.), Dudley et al.)
- Enhances the growth and self-renewal of mouse embryonic stem (ES) cells (Burdon et al.), Qi et al.)
- Permits derivation of mouse ES cells from the refractory CBA mouse strain (Buehr and Smith)
- Blocks the differentiation of mouse ES cells (Burdon et al.)
- Enhances adipogenic differentiation and blocks osteogenic differentiation of human mesenchymal stem cells (Jaiswal et al.)
- Decreases number of AML blast colonies with minimal effect on normal hematopoietic progenitors (Milella et al.)
Tekniske data
Tekniske data
| CAS | 167869-21-8 |
| Mængde | 1 mg |
| Molekylær formel | C16H13NO3 |
| Renhed | ≥98% |
Produkttitel
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