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Tocris Bioscience™ PD 0325901
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Artikelnummer. 18095742
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50 mg
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18095742 10 mg
18024142 50 mg
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Artikelnummer. 18095742 Leverandør Tocris Bioscience™ Leverandørnr. 4192/10

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Potent inhibitor of MEK1/2

PD 0325901 is a potent MEK1 and MEK2 inhibitor. PD 0325901 inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). PD 0325901 inhibits the growth of melanoma cell lines in vitro and in vivo; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. Also inhibits production of proangiogenic cytokines such as VEGF. Enhances generation of induced pluripotent stem cells (iPSCs). Orally active.

For more information about how PD 0325901 may be used, see our protocols: Culturing Transcriptomically Distinct Pluripotent mESCs, Highly Efficient Generation of CiPSCs from MEFs, Accelerated Induction of Cortical Neurons from hiPSCs .

TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 391210-10-9
Molekylær formel C16H14F3IN2O4

Tekniske data

Kemisk navn eller materiale PD 0325901
Mængde 10 mg
Formel vægt 482.19
Renhed >99%
Molekylvægt (g/mol) 482.198
Produkttitel
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