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Tocris Bioscience™ Ozanimod
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Artikelnummer. 18766096
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50 mg
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Artikelnummer. Mængde
18766096 10 mg
18768636 50 mg
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Artikelnummer. 18766096 Leverandør Tocris Bioscience™ Leverandørnr. 7663/10

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Beskrivelse

Potent and selective S1P1 and S1P5 agonist

Ozanimod is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist (EC50 values are 0.41 and 11 nM, respectively, in a [35S]-GTPγS assay). Ozanimod exhibits 27-fold selectivity over S1P5, and >10,000-fold selectivity over S1P2-4. In vitro, Ozanimod induces sustained S1P1 receptor internalization and degradation in S1P1 receptor-HEK293T cells. In vivo, Ozanimod reduces inflammation and disease parameters in rat models of autoimmune disease. Ozanimod reduces chronic inflammation and alleviates kidney pathology in a murine model of systemic lupus erythematosus. Ozanimod is orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 5-[3-[(1 S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1 H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
CAS 1306760-87-1
Mængde 10 mg
Mål Sphingosine-1-phosphate Receptor Agonists
Molekylær formel C23H24N4O3
Renhed 0.98
Produkttitel
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