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OSU-T315, MedChemExpress

Artikelnummer. 16443597
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Mængde:
5 mg
10 mg
50 mg
Pakningsstørrelse:
10mg
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Artikelnummer. 16443597 Leverandør Medchem Express Leverandørnr. HY18676

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MedChemExpress OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner. OSU-T315 causes cell death through apoptosis and autophagy.

OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner. OSU-T315 causes cell death through apoptosis and autophagy.

Tekniske data

Kemisk navn eller materiale OSU-T315
Fysisk form Solid
CAS 2070015-22-2
Farve White
Mængde 50 mg
Renhedsgrad noter Research
Molekylær formel C30H30F3N5O
Til brug med (applikation) Cancer-Kinase/protease
Opløselighedsinformation DMSO : ≥ 260 mg/mL (487.27 mM)
SMIL O=C(NC)CCC1=CC(C2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)=NN1C4=CC=C(N5CCNCC5)C=C4
Molekylvægt (g/mol) 533.59
Formel vægt 533.59
Procent renhed 98.0%
Grad Research
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Research purposes only

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