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ON123300, MedChemExpress

Artikelnummer. 16471477
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Artikelnummer. 16471477 Leverandør Medchem Express Leverandørnr. HY12624

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Beskrivelse

MedChemExpress ON123300, a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRβ (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent ON123300 causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors. ON123300 inhibits CDK6 with an IC50 of 9.82 nM.

ON123300, a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRβ (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent ON123300 causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors. ON123300 inhibits CDK6 with an IC50 of 9.82 nM.

Tekniske data

Kemisk navn eller materiale ON123300
Fysisk form Solid
CAS 1357470-29-1
Farve Orange
Mængde 50 mg
Renhedsgrad noter Research
Molekylær formel C24H27N7O
Til brug med (applikation) Cancer-Kinase/protease
Opløselighedsinformation DMSO : 16.67 mg/mL (38.81 mM; ultrasonic and warming and heat to 60°C)
SMIL N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O
Molekylvægt (g/mol) 429.52
Formel vægt 429.52
Procent renhed 99.34%
Grad Research
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Research purposes only

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