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Invitrogen™ Oligomer A11 Polyclonal Antibody

Artikelnummer. 10261863
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Mængde:
50 μg
Pakningsstørrelse:
Hver
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10261863 50 μg Hver
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Artikelnummer. 10261863 Leverandør Invitrogen™ Leverandørnr. AHB0052
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Beskrivelse

Rabbit Polyclonal Antibody

This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. A11 reacts with soluble AB42 oligomers and does not react with soluble low molecular weight AB40 or AB40 fibrils. A11 recognizes oligomeric species of several other amyloidogenic polypeptides including AB42, human insulin, prion, polyglutamine, lysozyme, alpha-synuclein and yeast prion Sup35. Oligomeric AB42 is recommended as a positive control, monomeric and fibrillar AB42 as negative controls.

Many degenerative diseases are known to be related to the accumulation of misfolded proteins called, amyloid fibrils. Soluble amyloid oligomers are considered as the principal pathogenic species which play an important role in the formation of amyloid fibrils; therefore, oligomers are involved in the pathogenesis of the many neurodegenerative diseases. This anti-oligomer antibody provides a facile means of assessing the significance of oligomers in disease pathogenesis.
TRUSTED_SUSTAINABILITY

Tekniske data

Antigen Oligomer A11
Applikationer Dot Blot, ELISA, Immunohistochemistry, Neutralization, Western Blot
Klassifikation Polyclonal
Koncentration 1.0 mg/mL
Konjugeret Unconjugated
Formulering PBS with 0.1% sodium azide; pH 7.4
Gene INS
Genadgangsnr. P01308, P01322, P01325
Gene Alias Antioligomer A11; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2-rs1; Insulin; insulin 1; Insulin A chain; Insulin B chain; insulin I; insulin-1; Insulin-1 A chain; Insulin-1 B chain; IRDN; MODY10; preproinsulin; proinsulin
Gensymboler INS, Ins1
Værtsarter Rabbit
Immunogen Synthetic molecular mimic of soluble oligomers.
Oprensningsmetode Purified
Mængde 50 μg
Regulatorisk status RUO
Primær eller sekundær Primary
Gen-id (Entrez) 16333, 24505, 3630
Målarter Human, Mouse, Rat
Indhold og opbevaring Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Produkttype Antibody
Form Liquid
Isotype IgG
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