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STEMCELL Technologies O6-Benzylguanine

Artikelnummer. 17140272
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50 mg
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17140272 50 mg
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Artikelnummer. 17140272 Leverandør STEMCELL Technologies Leverandørnr. 73762

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Beskrivelse

Epigenetic modifier; Inactivates methylguanine DNA methyltransferase (MGMT)

  • O6-Benzylguanine is an efficient irreversible inactivator of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT)
  • AGT directly removes alkyl groups located on the O6-position of guanine from DNA, thereby restoring DNA integrity
  • O6-Benzylguanine is an antineoplastic agent that can be used to investigate the role of AGT in carcinogenesis and mutagenesis (Pegg 2011; Dolan et al.)
  • Enhances the activity of alkylating agents (nitrosourea, temozolomide, and cyclophosphamide) in malignant glioma xenografts growing in athymic nude mice (Pegg 1990)
  • Sensitizes CD34+ hematopoietic progenitors and a breast cancer cell line to bis-chloroethylnitrosourea (BCNU; Gerson et al.)

Tekniske data

CAS 19916-73-5
Synonym NSC 637037
Mængde 50 mg
Molekylær formel C12H11N5O
Renhed ≥98%
Produkttitel
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