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STEMCELL Technologies (±)-Nutlin-3

Product Code. 17130272
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10 mg
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Product Code. 17130272 Supplier STEMCELL Technologies Supplier No. 73754

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Description

p53 pathway activator; Inhibits MDM2

  • (±)-Nutlin-3 is a small-imidazoline-based mouse double minute 2 (MDM2) protein antagonist which disrupts MDM2-p53 interaction (IC50 = 0.09 μM; Vassilev et al.) MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcriptional activity and stability
  • By disrupting this interaction, (±)-Nutlin-3 therefore promotes the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53 (Vassilev et al.), Gu et al.)

Specifications

CAS 548472-68-0
Mængde 10 mg
Molekylær formel C30H30Cl2N4O4
Renhed >98%
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