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STEMCELL Technologies NU7441

Artikelnummer. 17150322
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10 mg
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17150322 5 mg
17160322 10 mg
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Artikelnummer. 17150322 Leverandør STEMCELL Technologies Leverandørnr. 74082

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Beskrivelse

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

  • NU7441 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway
  • It is highly selective for DNA-PK, with an IC50 of 14 nM (Leahy et al.)
  • Reduces the frequency of NHEJ and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.)
  • Sensitizes human cancer cell lines to DNA double-strand-break-inducing therapies (chemo- or radio-therapy) by inhibiting DNA-PK activity and delaying the repair of double-strand breaks (Ciszewski et al.; Shaheen et al.; Yang et al.; Zhao et al.)

Tekniske data

CAS 503468-95-9
Synonym KU57788
Mængde 5 mg
Molekylær formel C25H19NO3S
Renhed ≥98%
Produkttitel
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