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Tocris Bioscience™ NR 7h
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Artikelnummer. 18717546
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Mængde:
5 mg
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18717546 5 mg
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Artikelnummer. 18717546 Leverandør Tocris Bioscience™ Leverandørnr. 7177/5

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Beskrivelse

Potent and selective p38α and p38β Degrader (PROTAC™); active in vivo

NR 7h is a potent and selective p38α and p38β Degrader (PROTAC™) (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. NR 7h impairs replication of Mayaro virus in human dermal fibroblasts and HeLa cells. Active in vivo.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2 H)-yl)-N-(4-(1-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)amino)-4-oxobutyl)-1 H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide
CAS 2550399-06-7
Mængde 5 mg
Mål Active Degraders
Molekylær formel C48H50BrF2N9O8
Formel vægt 3636
Renhed 97%
Produkttitel
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