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Tocris Bioscience™ NR 162
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Artikelnummer. 18737786
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Mængde:
10 mg
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18737786 10 mg
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Artikelnummer. 18737786 Leverandør Tocris Bioscience™ Leverandørnr. 7572/10

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Beskrivelse

Potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor

NR 162 is a potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor (IC50 = 80 nM); it exhibits no significant activity against related kinases MERTK, AXL and ABL1 and ~ 47-fold selectivity over TYRO3 (IC50 = 3.8 μM). NR 162 targets the unique pocket created by CASK GFG motif; it is a type-I inhibitor which stabilizes the active state of CASK without affecting the scaffolding function. NR 162 induces cell death in actively differentiating cells of the P19 neuronal differentiation model. NR 162 shows no toxicity in differentiated cells, or in cancer cells.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-(Cyclopentylamino)-2-((2,5-dibromo-4-methylbenzyl)amino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide
CAS 2755241-73-5
Mængde 10 mg
Mål CaM Kinase Inhibitors
Molekylær formel C24H30Br2N6O3
Produkttitel
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