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Novobiocin Sodium Salt, MP Biomedicals™
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Quantity:
1 g
5 g
25 g
Description
Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Novobiocin Sodium Salt, MP Biomedicals is an antibiotic produced by Streptomyces nieveus. It is active against gram-positive bacteria. It is also a Hsp90 inhibitor 3.
Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. It acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB 2. Uses include:
- For the production of positively supercoiled plasmid DNA
- Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase
- Inhibitor of retrovirus RNA-dependent DNA-polymerase
- To study heat shock protein inhibition
Specifications
Physical Form | Powder |
Absorbance | λ max: 307nm |
Melting Point | 220°C |
Extinction Coefficient | E1%= 600 (0.1M NAOH) |
Potency | ∼900μg/mg |
Solubility Information | Freely soluble in water (10%, clear, colorless solution) |
IUPAC Name | sodium 7-{[4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy}-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2,4-dioxo-3,4-dihydro-2H-1-benzopyran-3-ide |
Formula Weight | 634.6 |
Quantity | 1 g |
Optical Rotation | −38.0° (2.5g/100ml ethanol at 24°C for the free acid) |
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