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  6. Novobiocin Sodium Salt, MP Biomedicals™

Novobiocin Sodium Salt, MP Biomedicals™

Catalog Number 11499251
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Quantity:
1 g
5 g
25 g
This item is not returnable. View return policy
1476-53-5
C31H35N2NaO11
634.61
MFCD00066541,MFCD00066541
AXOUUAINTJNFRS-UHFFFAOYNA-N
Albamycin, Cathomycin sodium
131673945
[Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=O)[C-](NC(=O)C4=CC=C(O)C(CC=C(C)C)=C4)C(=O)OC3=C2C)OC1(C)C
This item is not returnable. View return policy
1476-53-5
C31H35N2NaO11
634.61
MFCD00066541,MFCD00066541
AXOUUAINTJNFRS-UHFFFAOYNA-N
Albamycin, Cathomycin sodium
131673945
[Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=O)[C-](NC(=O)C4=CC=C(O)C(CC=C(C)C)=C4)C(=O)OC3=C2C)OC1(C)C

Description

Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Novobiocin Sodium Salt, MP Biomedicals is an antibiotic produced by Streptomyces nieveus. It is active against gram-positive bacteria. It is also a Hsp90 inhibitor 3.

Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. It acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB 2. Uses include:

  • For the production of positively supercoiled plasmid DNA
  • Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase
  • Inhibitor of retrovirus RNA-dependent DNA-polymerase
  • To study heat shock protein inhibition
Physical Form Powder
Absorbance λ max: 307nm
Melting Point 220°C
Extinction Coefficient E1%= 600 (0.1M NAOH)
Potency ∼900μg/mg
Solubility Information Freely soluble in water (10%, clear, colorless solution)
IUPAC Name [(3R,4S,5R,6R)-5-hydroxy-6-[4-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-2-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate;molecular hydrogen;sodium
Formula Weight 634.6
Quantity 25 g
Optical Rotation −38.0° (2.5g/100ml ethanol at 24°C for the free acid)
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