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Novobiocin Sodium Salt, MP Biomedicals™

Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Novobiocin Sodium Salt, MP Biomedicals is an antibiotic produced by Streptomyces nieveus. It is active against gram-positive bacteria. It is also a Hsp90 inhibitor 3.

Brand:  MP Biomedicals 0215595725

Additional Details : CAS Number : 1476-53-5 Weight : 0.01000kg

Quantity 25g

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Product Code. 11499251

  • POA / 25g

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Description

Description

Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. It acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB 2. Uses include:

  • For the production of positively supercoiled plasmid DNA
  • Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase
  • Inhibitor of retrovirus RNA-dependent DNA-polymerase
  • To study heat shock protein inhibition
Specifications

Chemical Identifiers

1476-53-5
637.638
Albamycin, Cathomycin sodium
[(3R,4S,5R,6R)-5-hydroxy-6-[4-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-2-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate;molecular hydrogen;sodium
C31H38N2NaO11
GRTHVRCAUMNVTO-CVIUYYTNSA-N
131673945
[HH].CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)O)CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na]

Specifications

λ max: 307nm
E1%= 600 (0.1M NAOH)
Albamycin, Cathomycin sodium
GRTHVRCAUMNVTO-CVIUYYTNSA-N
[HH].CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)O)CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na]
637.638
634.6
1.3448g/mL
25g
1476-53-5
C31H38N2NaO11
Freely soluble in water (10%, clear, colorless solution)
∼900μg/mg
[(3R,4S,5R,6R)-5-hydroxy-6-[4-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-2-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate;molecular hydrogen;sodium
131673945
White Powder
220°C
−38.0° (2.5g/100ml ethanol at 24°C for the free acid)
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