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  6. Nolatrexed dihydrochloride, MedChemExpress

Nolatrexed dihydrochloride, MedChemExpress

Artikelnummer. 16476917
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16476917 5 mg
16470547 50 mg
16414208 10 mg
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Artikelnummer. 16476917 Leverandør Medchem Express Leverandørnr. HY108474

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Beskrivelse

MedChemExpress Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.

Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.

Tekniske data

Kemisk navn eller materiale Nolatrexed dihydrochloride
Fysisk form Solid
CAS 152946-68-4
Farve Yellow
Mængde 5 mg
Renhedsgrad noter Research
Molekylær formel C14H14Cl2N4OS
Til brug med (applikation) Cancer-programmed cell death
Synonym AG 337 Thymitaq
Opløselighedsinformation H2O : 50 mg/mL (139.95 mM; Need ultrasonic) ∣DMSO : 41.67 mg/mL (116.64 mM; Need ultrasonic)
SMIL [H]Cl.O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl
Molekylvægt (g/mol) 357.26
Formel vægt 357.26
Procent renhed 98.54%
Grad Research
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Research purposes only

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