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STEMCELL Technologies Nocodazole

Artikelnummer. 17130322
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50 mg
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17130322 10 mg
17140322 50 mg
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Artikelnummer. 17130322 Leverandør STEMCELL Technologies Leverandørnr. 74072

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Beskrivelse

Microtubule polymerization inhibitor; Inhibits beta-tubulin

  • Nocodazole is an anti-mitotic agent that reversibly interferes with the polymerization of microtubules (De Brabander et al.) Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics, impairing formation of the metaphase spindles during the cell division cycle
  • This prevents mitosis by inducing a G2/M-phase arrest and induces apoptosis in tumor cells (Jordan et al.)
  • Synchronizes human pluripotent stem cells (hPSCs) in the G2/M cell cycle phase, thereby increasing the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Lin et al.; Yang et al.)
  • Induces apoptosis in leukemic cells without harming T cells and/or mesenchymal stromal cells that were recovered from the same patients (Frezzato et al.)

Tekniske data

CAS 31430-18-9
Synonym NSC 238159; Oncodazole; R 17934
Mængde 10 mg
Molekylær formel C14H11N3O3S
Renhed ≥98%
Produkttitel
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