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Tocris Bioscience™ Nintedanib
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Artikelnummer. 18756736
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10 mg
50 mg
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18756736 10 mg
18719796 50 mg
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Artikelnummer. 18756736 Leverandør Tocris Bioscience™ Leverandørnr. 7049/10

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Beskrivelse

Potent VEGFR, PDGFR and FGFR inhibitor

Nintedanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC50 values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC50 values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate
CAS 656247-17-5
Mængde 10 mg
Molekylær formel C31H33N5O4
Renhed 98%
Produkttitel
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