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Niclosamide, MP Biomedicals™

Artikelnummer. 11425031 Shop alle MP Biomedicals produkter
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250 g
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Product Code. 11425031 Supplier MP Biomedicals Supplier No. 0215582783

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Description

Niclosamide ≥98%, Greenish-Yellow Powder

  • It is used to study the Wnt/Frizzled-1 signaling pathway.
  • It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and to induce apoptosis.
  • It is effective against cestodes that infect humans.
  • Niclosamide uncouples oxidative phosphorylation in the tapeworm.
  • It inhibits mitochondrial oxidative phosphorylation of parasitic helminths.
  • It inhibits the NF-κB pathway in acute myelogenous leukemia (AML) cells.
  • Niclosamide inhibits the transcription and DNA binding of NF-κB.
  • It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB– regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 50-65-7
Molekylær formel C13H8Cl2N2O4
Molekylvægt (g/mol) 327.12
MDL nummer MFCD00057597
InChI nøgle RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Synonym 2´,5-Dichloro-4-nitrosalicylanilide
IUPAC navn 5-chlor-N-(2-chlor-4-nitrophenyl)-2-hydroxybenzamid
SMIL OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C(C=C1Cl)[N+]([O-])=O

Specifications

Smeltepunkt 225°C to 233°C
Farve Green-yellow
Tab ved tørring ≤0.5%
Mængde 250 g
FN nummer UN3077
Beilstein 2820605
Opløselighedsinformation Soluble in methanol:acetone [1:1] (50mg/mL).
Damptryk Very low at room temp
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