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Tocris Bioscience™ NFκB p50 Transcription Factor Assay
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Artikelnummer. 18798036
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25 mg
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Artikelnummer. Mængde
18798036 25 mg
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Artikelnummer. 18798036 Leverandør Tocris Bioscience™ Leverandørnr. 7051/25

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Beskrivelse

Indeholder

  • Transcription Factor Assay Plate
  • TFA Buffer, 5x
  • Blocking Reagent
  • Blocking Reagent
  • Primary Antibody
  • Gt X Rb, HRP Secondary Antibody
  • NFkB Capture Probe
  • NFkB Specific Competitor Oligonucleotide
  • TFA Negative Control Probe
  • HeLa Whole Cell Extract, TNFalpha Treated
  • Substrate (TMB/E)
  • Stop Solution

The transcription factor NFkB is involved in the expression and regulation of a number of important cellular and physiological processes such as growth, development, apoptosis, immune and inflammatory response

Tasquinimod is a high affinity negative allosteric modulator of HDAC4 (Kd = 10 - 30 nM). Binds the regulatory Zn2+ binding domain of HDAC4. Suppresses hypoxia-induced decrease in histone acetylation in human prostate cancer cells in vitro. Also binds S100A9. Antiangiogenic. Inhibits endothelial sprouting in vitro and growth of prostate tumor xenografts in nude mice. Orally bioavailable.
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Mængde 25 mg
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