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Tocris Bioscience™ Nepicastat hydrochloride
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Artikelnummer. 18788208
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Mængde:
10 mg
50 mg
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Artikelnummer. Mængde
18788208 10 mg
18744068 50 mg
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Artikelnummer. 18788208 Leverandør Tocris Bioscience™ Leverandørnr. 5037/10

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Beskrivelse

Potent and selective dopamine β-hydroxylase (DBH) inhibitor; orally bioavailable

Nepicastat hydrochloride is a potent and selective dopamine β-hydroxylase (DBH) inhibitor (IC50 = 9 nM) . Selective for DBH over 12 other enzymes. Decreases noradrenaline and increases dopamine levels in tissues and plasma in hypertensive rats. Prevents progressive left ventricular dysfunction in an in vivo heart failure model. Also potentiates the stimulus effects of cocaine without producing cocaine-like effects in rats. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride
CAS 170151-24-3
Mængde 10 mg
Mål Hydroxylase Inhibitors
Molekylær formel C14H15F2N3S.HCl
Formel vægt 331.81
Renhed >98%
Produkttitel
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