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NAT1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA522298
Additional Details : Weight : 0.01000kg
Description
Recommended positive controls: 293T, A431, HeLa, HepG2. Predicted reactivity: Rabbit (81%), Bovine (83%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a wide array of drugs. Certain alleles causing high N-acetyltransferase activity have been associated with colon and urinary bladder cancers, as NATs also bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins and play an active role in the detoxification of many arylamine and hydrazine drugs. N-acetylation polymorphism is determined by the level of NAT activity in liver tissues, and has been linked to the action and toxicity of drugs that contain amines. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 is the functional homolog of rodent NAT-1.Specifications
| NAT1 | |
| Polyclonal | |
| Unconjugated | |
| NAT1 | |
| AAC1; Arylamide acetylase 1; arylamine N-acetyltransferase 1; AT-1; MNAT; Monomorphic arylamine N-acetyltransferase; N(alpha)-acetyltransferase 15, NatA auxiliary subunit; N-acetyl transferase 1; N-acetyl transferase 1, liver, blood; N-acetyltransferase (arylamine N-acetyltransferase); N-acetyltransferase 1; N-acetyltransferase 1 (arylamine N-acetyltransferase); N-acetyltransferase type 1; Nat; Nat1; NAT-1; NATI | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 9 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 0.65 mg/mL | |
| 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
| P18440 | |
| NAT1 | |
| Recombinant fragment corresponding to a region within amino acids 1 and 187 of NAT1 (Uniprot ID#P18440) | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |