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Tocris Bioscience™ MRTX 849
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Artikelnummer. 18728066
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50 mg
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18728066 50 mg
18717386 10 mg
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Artikelnummer. 18728066 Leverandør Tocris Bioscience™ Leverandørnr. 7488/50

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Beskrivelse

Mutation-selective inhibitor of KRASG12C

MRTX 849 is a mutant-selective inhibitor of KRASG12C (IC50 = 142 nM). MRTX 849 covalently binds to KRASG12C at the cysteine at residue 12 and inhibits KRAS-dependent signal transduction by locking the protein in its inactive GDP-bound state. MRTX 849 induces pronounced tumor regression in 17 of 26 (65%) KRASG12C -positive cell lines and patient-derived xenograft models from multiple tumor types. It is orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
CAS 2326521-71-3
Mængde 50 mg
Mål Ras GTPase Inhibitors
Molekylær formel C32H35ClFN7O2
Renhed 98%
Produkttitel
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