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STEMCELL Technologies MLN4924

Artikelnummer. 17140342
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Mængde:
1 mg
10 mg
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Artikelnummer. Mængde
17140342 1 mg
17150342 10 mg
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Artikelnummer. 17140342 Leverandør STEMCELL Technologies Leverandørnr. 74182

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Beskrivelse

Inhibits NEDD8-activating enzyme

  • MLN4924 inhibits cullin neddylation by directly targeting the NEDD8-activating enzyme that is essential for the activity of cullin-RING ligase (CRL) (Nawrocki et al.) The components of CRL are frequently up-regulated in human cancers (Zhao & Sun), and MLN4924 was reported to suppress the growth of human tumor xenografts in mice (Soucy et al.)
  • In combination with other small molecules ('CRISPY' mix), MLN4924 has been reported to increase precise CRISPR-Cas9 genome editing in human pluripotent stem cells (Riesenberg & Maricic)
  • By blocking NAE and proteasome, MLN4924 together with bortezomib inhibits AKT and mTOR and induces apoptosis in multiple myeloma cell lines (Gu et al.)

Tekniske data

CAS 905579-51-3
Synonym Pevonedistat
Mængde 1 mg
Molekylær formel C21H25N5O4S
Renhed ≥98%
Produkttitel
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