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ML218, MedChemExpress

Artikelnummer. 16476547
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Mængde:
5 mg
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Artikelnummer. Mængde
16476547 5 mg
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Artikelnummer. 16476547 Leverandør Medchem Express Leverandørnr. HY103309

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Beskrivelse

MedChemExpress ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier.

ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier.

Tekniske data

Kemisk navn eller materiale ML218
Fysisk form Solid
CAS 1346233-68-8
Farve Light Yellow
Mængde 5 mg
Renhedsgrad noter Research
Molekylær formel C19H26Cl2N2O
Til brug med (applikation) Neuroscience-Neuromodulation
Opløselighedsinformation DMSO : 125 mg/mL (338.45 mM; Need ultrasonic)
SMIL O=C(NC[C@@H]1[C@@]2([H])CN(CCC(C)(C)C)C[C@@]12[H])C3=CC(Cl)=CC(Cl)=C3
Molekylvægt (g/mol) 369.33
Formel vægt 369.33
Procent renhed 99.18%
Grad Research
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Research purposes only

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