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Tocris Bioscience™ ML 162
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Artikelnummer. 30000030
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50 mg
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30000030 10 mg
30000010 50 mg
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Artikelnummer. 30000030 Leverandør Tocris Bioscience™ Leverandørnr. 7821/10

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Beskrivelse

Inhibits glutathione peroxidase (GPX4); induces ferroptosis

ML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50 = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).
TRUSTED_SUSTAINABILITY

Specifications

Kemisk navn eller materiale 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide
CAS 1035072-16-2
Mængde 10 mg
Mål Glutathione Peroxidase 4/GPX4
Molekylær formel C23H22Cl2N2O3S
Renhed 0.98
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