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Tocris Bioscience™ MK 2206 dihydrochloride
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Artikelnummer. 30000037
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30000037 50 mg
30000034 10 mg
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Artikelnummer. 30000037 Leverandør Tocris Bioscience™ Leverandørnr. 7850/50

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Beskrivelse

Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor

MK 2206 dihydrochloride is a potent and selective allosteric Akt inhibitor (IC50 values are 5 nM, 12 nM, and 65 nM for Akt1, Akt2, and Akt3, respectively). MK 2206 requires the Pleckstrin homology domain for its activity, and exhibits no inhibitory activity in a panel of 250 tested protein kinases. MK 2206 induces growth inhibition of different cancer cell lines (IC50 in the range 3.4 and 28.6 μmol/L) and enhances antitumor efficacy of a range of standard chemotherapeutics. It synergistically inhibits cell proliferation of human lung and breast cancer cells in combination with Erlotinib (Cat. No. 7194) by suppressing both the Ras/Erk and PI 3-K pathways in vitro and in vivo. MK 2206 can be used to block the IL-22 - Akt signaling pathway for studying paneth cell differentiation.
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Tekniske data

Kemisk navn eller materiale 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
CAS 1032350-13-2
Mængde 50 mg
Mål Akt (Protein Kinase B) Inhibitors
Molekylær formel C25H21N5O.2HCl
Renhed 0.98
Produkttitel
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