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STEMCELL Technologies Mitomycin C
Beskrivelse
- Mitomycin C is an antibiotic which acts as a double-stranded DNA alkylating agent
- It covalently crosslinks DNA, inhibiting DNA synthesis and cell proliferation
- It acts by way of reductive activation either through low pH or NAD(P)H:quinone oxidoreductase (DT-diaphorase) or NADH cytochrome c reductase (Mao et al.; Cummings et al.)
- Mitotically inactivates mouse embryonic fibroblasts (MEFs) for use as feeder cell layers in embryonic stem cell co-culture systems (Bryja et al.)
- Selectively inhibits DNA synthesis and mutagenesis, stimulates genetic recombination, chromosome breakage and sister chromatid exchange, and induces DNA repair (Tomasz)
Tekniske data
Tekniske data
| CAS | 50-07-7 |
| Mængde | 10 mg |
| Procent renhed | ≥98% |
Produkttitel
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