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Tocris Bioscience™ Mirabegron
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Artikelnummer. 18798936
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Mængde:
5 mg
25 mg
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Artikelnummer. Mængde
18798936 5 mg
18777116 25 mg
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Artikelnummer. 18798936 Leverandør Tocris Bioscience™ Leverandørnr. 7070/5

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Beskrivelse

Potent and selective β3 agonist

Mirabegron is a potent and selective β3-adrenoceptor agonist (EC50 = 22.4 nM). Displays >440-fold selectivity for β3 over β1 and β2 adrenoceptors. Increases cAMP concentration in CHO cells expressing human β3-adrenoceptor. Displays relaxant effect in ex vivo rat bladder muscle preparation precontracted with carbachol (Cat. No. 2810). Decreases frequency of bladder contraction in rats. Also promotes browning of white adipose tissue, reduces body weight, and improves glucose tolerance and insulin sensitivity in mice fed a high fat diet.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
CAS 223673-61-8
Mængde 5 mg
Molekylær formel C21H24N4O2S
Renhed 98%
Produkttitel
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