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Invitrogen™ Human MET [M1250T], His Tag Recombinant Protein

Artikelnummer. 15498583
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Mængde:
1 mg
100 μg
Pakningsstørrelse:
100µg
1mg
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Artikelnummer. 15498583

Brand: Invitrogen™ PR7432A

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
TRUSTED_SUSTAINABILITY

Tekniske data

Koncentration See Label
Til brug med (applikation) Kinase Assay
Formulering 50 mM tris HCl with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
Molekylvægt (g/mol) 53.7 kDa
Navn Human MET [M1250T], His Tag
Mængde 100 μg
Regulatorisk status RUO - research use only
Fælles navn MET (M1250T Mutant)
KinaseFamily MET (HGFR) Kinase Family
Protein længde 956-1390; M1250T
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Protein tag His-tag
Indhold og opbevaring -80°C, Avoid Freeze/Thaw Cycles
Udtrykssystem Insect cells
Form Liquid
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