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Invitrogen™ Human MELK, GST Tag Recombinant Protein

Artikelnummer. 10388323
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Mængde:
10 μg
Pakningsstørrelse:
Hver
Artikelnummer. Mængde unitSize
10388323 10 μg Hver
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Artikelnummer. 10388323

Brand: Invitrogen™ PV4823

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic

MELK is a serine/threonione kinase which is related to the AMPK family that has been linked to the cell cycle. MELK has also been shown to be overexpressed in cancer and has been identified has a potential target for cancer therapeutics. MELK has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer Q14680
Koncentration See Label
Til brug med (applikation) Kinase Assay
Formulering 50 mM tris with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
Gen-id (Entrez) 9833
Molekylvægt (g/mol) 66.8 kDa
Navn Human MELK, GST Tag
Mængde 10 μg
Regulatorisk status For research use only. Not for use in diagnostic procedures
Gene Alias AI327312; hMELK; HPK38; Kiaa0175; Maternal embryonic leucine zipper kinase; Melk; mKIAA0175; MPK38; OTTHUMP00000046113; pEg3 kinase; Pk38; Protein kinase Eg3; protein kinase PK38; RP11-8N6.1; Tyrosine-protein kinase MELK
Fælles navn MELK
KinaseFamily CAMKL
Protein længde 1-340
Produkttype MELK Recombinant Human Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Protein tag GST-tag
Indhold og opbevaring -80°C, Avoid Freeze/Thaw Cycles
Udtrykssystem Insect cells
Protein familie Kinase and inhibitors
Form Liquid
Protein undertype Serine/threonine kinase
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