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Tocris Bioscience™ Masitinib
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Artikelnummer. 18778176
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50 mg
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Artikelnummer. Mængde
18778176 10 mg
18767206 50 mg
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Artikelnummer. 18778176 Leverandør Tocris Bioscience™ Leverandørnr. 7705/10

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Beskrivelse

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

Masitinib is a potent inhibitor of the tyrosine kinase receptor colony-stimulating factor 1R (CSF-1R) (IC50 = 90 nM). It is also an NLRP3 inflammasome activator. Masitinib additionally inhibits the proteolytic activity of SARS-CoV-2 main protease (Mpro) and blocks viral replication, as well as acting as a PDGFRα/β inhibitor. In vivo, Masitinib ameliorates cognitive impairment in transgenic mice model of Alzheimer's disease, and slows disease progression in a rat model of amyotrophic lateral sclerosis (ALS). Orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
CAS 790299-79-5
Mængde 10 mg
Mål CD117/c-kit
Molekylær formel C28H30N6OS
Renhed 0.98
Produkttitel
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