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LYVE1 Monoclonal Antibody (ALY7), Alexa Fluor™ 488, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

1560.00 DKK - 3575.00 DKK

Specifications

Antigen LYVE1
Clone ALY7
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen)
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15371990
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Affymetrix eBioscience
53-0443-80
25 μg
1560.00 DKK
25µg
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15381990
View Documents Promotion Details
Affymetrix eBioscience
53-0443-82
100 μg
3575.00 DKK
100µg
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In Stock
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Description

Description

Description: The monoclonal antibody ALY7 recognizes mouse LYVE-1, a transmembrane glycoprotein with similarity to CD44. The extracellular domain contains a conserved hyaluro binding domain also found in CD44. Expression is found on lymphatic and liver endothelial cells and some populations of macrophages. The lymphatic system is responsible for transporting proteins and cells (especially dendritic cells) to tissues throughout the body, thereby acting as immune surveyors. LYVE-1 is one characteristic protein, along with podoplanin, PROX-1, Tie-2 and VEGFR-3, that is expressed on lymphatic endothelial cells (LECS). The ligand for LYVE-1 is hyaluro, a large mucopolysaccharide. Although LYVE-1 can bind hyaluro in vitro, the site for ligand binding in vivo is masked by sialyated O-linked glycan chains. It is postulated that binding to ligand requires modification/unmasking to expose the binding site. The development and remodeling of the endothelium after injury is an area of extensive study. When transplanted, hematopoietic stem cells (HSCs) can give rise to LECs that integrate into the endothelium in normal and metastatic tissue. Applications Reported: This ALY7 antibody has been reported for use in flow cytometric analysis and immunohistologic staining of frozen tissue sections. Applications Tested: This ALY7 antibody has been tested by immunofluorescence microscopy on mouse intestine. This can be used at less than or equal to 2 μg/mL.

LYVE1 Monoclonal antibody specifically detects LYVE1 in Mouse samples. It is validated for Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen).
Specifications

Specifications

LYVE1
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
1200012G08Rik; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; CRSBP1; CRSBP-1; extra cellular link domain-containing 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1; HAR; hyaluronic acid receptor; lymphatic endothelial hyaluronan receptor LYVE-1; lymphatic vessel endothelial HA receptor-1; lymphatic vessel endothelial HA recptor-1; lymphatic vessel endothelial hyaluronan receptor 1; lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE1; LYVE-1; sLyve 1; sLyve1; soluble LYVE 1; soluble LYVE1; UNQ230/PRO263; XLKD1
Lyve1
Primary
4° C, store in dark, DO NOT FREEZE!
Lyve1
ALY7
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen)
Alexa Fluor 488
Rat
Mouse
Q8BHC0
114332
IgG1 κ
Affinity chromatography
Antibody
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