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STEMCELL Technologies LY2228820 (Dimesylate)

Artikelnummer. 17110342
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Mængde:
1 mg
5 mg
Pakningsstørrelse:
1mg
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17110342 5 mg -
17100342 1 mg 1mg
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Artikelnummer. 17110342 Leverandør STEMCELL Technologies Leverandørnr. 74164

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Beskrivelse

p38 MAP kinase (MAPK) inhibitor

  • LY2228820 is a trisubstituted imidazole derivative and a potent inhibitor of the α- and β-isoforms of p38 MAP kinase (MAPK) in vitro (IC50 = 5.3 and 3.2 nM, respectively) with anti-inflammatory and anti-neoplastic activities (Campbell et al.) This product is supplied as the dimesylate salt of the molecule
  • Combined with other small molecule inhibitors such as Rapamycin (Catalog #73362) and SR1 (Catalog #72342; Li et al.) or SB203580 (Catalog #72222), Vx702, and BIRB-796 (Catalog #72682), enhances the self-renewal of cord blood-derived hematopoietic stem cells (Baudet et al.)
  • By inhibiting p38 MAPK, which is highly expressed in human cancers, LY2228820 is potent and selective at inhibiting tumor growth in animal models of a variety of human cancers (Campbell et al.)

Tekniske data

CAS 862507-23-1
Synonym Ralimetinib Mesylate; LSN2322600
Mængde 5 mg
Molekylær formel C24H29FN6 · 2CH3SO3H
Renhed ≥98%
Produkttitel
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